Synthesis and preliminary antiproliferative evaluation of 1,3,9-triazacyclopenta[b]fluorene derivatives

Novel 1,3,9-triazacyclopenta[b]fluorene-4,10-diones and 1,3,9-triazacyclopenta[b]fluorene, analogue of ellipticine, were synthesised, and evaluated in vitro for their antiproliferative activity on various breast cancer cell lines.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2005-12, Vol.20 (6), p.569-574
Hauptverfasser:	Desforges, Gwenaelle, Picot, Laurent, Montagne, Cyril, Thiéry, Valérie, Besson, Thierry, Joseph, Benoit
Format:	Artikel
Sprache:	eng
Schlagworte:	1,3,9-Triazacyclopenta[b]fluorene antiproliferative activity bioisostere breast cancer cell lines Breast Neoplasms - drug therapy Carbazoles - chemical synthesis Carbazoles - chemistry Carbazoles - pharmacology Cell Line, Tumor Cell Proliferation - drug effects Drug Screening Assays, Antitumor ellipticine Female Fluorenes - chemical synthesis Fluorenes - chemistry Fluorenes - pharmacology Humans Imidazoles - chemical synthesis Imidazoles - chemistry Imidazoles - pharmacology In Vitro Techniques Molecular Structure Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	Novel 1,3,9-triazacyclopenta[b]fluorene-4,10-diones and 1,3,9-triazacyclopenta[b]fluorene, analogue of ellipticine, were synthesised, and evaluated in vitro for their antiproliferative activity on various breast cancer cell lines.
ISSN:	1475-6366 1475-6374
DOI:	10.1080/14756360500212621