Microbial Hydroxylation of Androsta-1, 4-diene-3, 17-dione

Microbial Hydroxylation of Androsta-1, 4-diene-3, 17-dione

The possibility for hydroxylations of androsta-1, 4-diene-3, 17-dione (ADD, II) was studied using different strains of the fungi Penicillium raistrickii, Aspergillus ochraceus, Curvularia lunata and Beauveria bassiana. The isolated products were 15α-hydroxy-ADD (III, P. raistrickii), 11α-hydroxy-ADD...

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Veröffentlicht in:Natural product letters 1995-02, Vol.6 (1), p.7-14
Hauptverfasser: Breiter, Steffen, Schlosser, Dietmar, Weiss, Dieter, Schmauder, Hans-Peter
Format: Artikel
Sprache:eng
Schlagworte:
11α-hydroxy-androsta-1
14-hydroxy-androsta-1
15α-hydroxy-androsta-1
17-dione
4-diene-3
7α, 11α-dihydroxy-androsta-1
androsta-1
Aspergillus ochraceus
Beauveria bassiana
Curvularia lunata
hydroxylation
Penicillium raistrickii
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Zusammenfassung:The possibility for hydroxylations of androsta-1, 4-diene-3, 17-dione (ADD, II) was studied using different strains of the fungi Penicillium raistrickii, Aspergillus ochraceus, Curvularia lunata and Beauveria bassiana. The isolated products were 15α-hydroxy-ADD (III, P. raistrickii), 11α-hydroxy-ADD (IV, A. ochraceus, B. bassiana), 14-hydroxy-ADD (V, C. lunata) and 7α, 11α-dihydroxy-ADD (VI, B. bassiana). Yields were observed up to 70%. The structures were elucidated by 1 H-NMR, 13 C-NMR, 2d-NMR, MS and UV/VIS.
ISSN:1057-5634
DOI:10.1080/10575639508044081