Perspectives on the Mechanism of ATP Hydrolysis by Nitrogenase

Perspectives on the Mechanism of ATP Hydrolysis by Nitrogenase

The chemical mechanism of ATP hydrolysis by nitrogenase is discussed in terms of results from isotopic exchange studies using [ 18 O 4 ]-Pi, b,g-[ 18 O]-ATP, and g-[ 18 O 4 ]-ATP as probes of reversibility (ATP = ADP + Pi) and of the freedom of rotation around the O-P b bond in enzyme-bound ADP.

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Veröffentlicht in:Phosphorus, sulfur, and silicon and the related elements sulfur, and silicon and the related elements, 1999-01, Vol.144 (1), p.513-516
Hauptverfasser: Krause, Stephan O., Gutheil, William G., Simeonov, Anton M., Matsunaga, Terry O., Stauber, Margaret J., Kenyon, George L., Mckenna, Charles E.
Format: Artikel
Sprache:eng
Schlagworte:
ATP
ATP hydrolysis
Nitrogenase
P NMR
HRMS
phosphate
PIX
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Zusammenfassung:The chemical mechanism of ATP hydrolysis by nitrogenase is discussed in terms of results from isotopic exchange studies using [ 18 O 4 ]-Pi, b,g-[ 18 O]-ATP, and g-[ 18 O 4 ]-ATP as probes of reversibility (ATP = ADP + Pi) and of the freedom of rotation around the O-P b bond in enzyme-bound ADP.
ISSN:1042-6507
1563-5325
DOI:10.1080/10426509908546294