EFFICIENT AND CHEMOSELECTIVE PROTECTION OF ALCOHOLS AND PHENOLS WITH Tert-BUTYLDIMETHYLCHLOROSILANE (TBDMCS) UNDER SOLVENT-FREE CONDITIONS

EFFICIENT AND CHEMOSELECTIVE PROTECTION OF ALCOHOLS AND PHENOLS WITH Tert-BUTYLDIMETHYLCHLOROSILANE (TBDMCS) UNDER SOLVENT-FREE CONDITIONS

Various types of primary and secondary alcohols and phenols can be converted efficiently to their corresponding TBDMS ethers using TBDMCS/imidazole under solvent-free conditions. Elimination of DMF, accompanied with an easy non-aqueous work-up and a high rate enhancement of the reaction are worthy t...

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Veröffentlicht in:Phosphorus, sulfur, and silicon and the related elements sulfur, and silicon and the related elements, 1998-12, Vol.143 (1), p.45-51
Hauptverfasser: Firouzabadi, Habib, Etemadi, Shahrad, Karimi, Babak, Jarrahpour, Ali Asghar
Format: Artikel
Sprache:eng
Schlagworte:
Protecting groups
Protection
Silyl EthersTBDMS Ethers
Silylation
Solvent-Free Condition
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Zusammenfassung:Various types of primary and secondary alcohols and phenols can be converted efficiently to their corresponding TBDMS ethers using TBDMCS/imidazole under solvent-free conditions. Elimination of DMF, accompanied with an easy non-aqueous work-up and a high rate enhancement of the reaction are worthy to be mentioned for the presented method. The reactions show absolute chemoselectivity for the protection of primary in the presence of secondary alcohols.
ISSN:1042-6507
1563-5325
DOI:10.1080/10426509808045483