The Quest for β-Thiolactam Antibiotics

Thioketenes or thioketene equivalents give β-thiolactams in the reaction with C=N systems, but problems arise in the synthesis of highly functionalized derivatives. Therefore to obtain the thione analog of a bactam a thionation approach was chosen.

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Bibliographische Detailangaben
Veröffentlicht in:	Phosphorus, sulfur, and silicon and the related elements sulfur, and silicon and the related elements, 1997-01, Vol.120 (1), p.349-350
Hauptverfasser:	Schaumann, Ernst, Nieschalk, Jens, Isecke, Rainer, Spanka, Carsten, Mrotzek, Herbert, Förster, Wolf-Rüdiger
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Thioketenes or thioketene equivalents give β-thiolactams in the reaction with C=N systems, but problems arise in the synthesis of highly functionalized derivatives. Therefore to obtain the thione analog of a bactam a thionation approach was chosen.
ISSN:	1042-6507 1563-5325
DOI:	10.1080/10426509708545543