BONE MINERAL DENSITY IN IRANIAN ADOLESCENTS AND YOUNG ADULTS WITH β-THALASSEMIA MAJOR

BONE MINERAL DENSITY IN IRANIAN ADOLESCENTS AND YOUNG ADULTS WITH β-THALASSEMIA MAJOR

The authors investigated the prevalence of low bone mass in patients from Tehran, Iran, with β-thalassemia major (n = 203), aged 10-20 years, and the potential risk factors for osteoporosis in this patient population. Prevalence of osteoporosis was 50.7% in lumbar spine, 10.8% in femur, and 7.9% in...

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Veröffentlicht in:Pediatric hematology and oncology 2007-01, Vol.24 (7), p.469-479
Hauptverfasser: Shamshirsaz, A. A., Bekheirnia, M. R., Kamgar, M., Pakbaz, Z., Tabatabaie, S. M., Bouzari, N., Pourzahedgilani, N., Azarkeivan, A., Hashemi, S. R., Moosavi, F., Alebouyeh, M., Vosough, P., Kimiagar, M., Moradi, M., Habibzadeh, M. R., Nobakhthaghighi, N., Larijani, B.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
beta-Thalassemia - complications
beta-Thalassemia - physiopathology
Bone Density
Bone Diseases, Metabolic - epidemiology
Bone Diseases, Metabolic - etiology
bone mineral density
Child
Female
Fractures, Bone - epidemiology
Humans
Iran - epidemiology
Male
osteopenia
osteoporosis
Osteoporosis - epidemiology
Osteoporosis - etiology
Osteoporosis - physiopathology
Prevalence
thalassemia
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Zusammenfassung:The authors investigated the prevalence of low bone mass in patients from Tehran, Iran, with β-thalassemia major (n = 203), aged 10-20 years, and the potential risk factors for osteoporosis in this patient population. Prevalence of osteoporosis was 50.7% in lumbar spine, 10.8% in femur, and 7.9% in both regions with no significant difference between the two genders. The following factors were associated with low BMD: height for age and weight for age below 3rd percentile, delayed puberty or hypogonadism, age when Desferal (for iron chelation) was started, duration of Desferal therapy, and serum zinc. Low serum copper and 25(OH)D were not associated with low BMD.
ISSN:0888-0018
1521-0669
DOI:10.1080/08880010701533702