Two Hydrolase Resistant Analogues of Diadenosine 5′,5″′-P,P-Triphosphate for Studies with FHIT, The Human Fragile Histidine Triad Protein

The design and synthesis of analogues of diadenosine 5′,5″′-P,P-triphosphate that are resistant to pyrophosphate hydrolysis is described in relation to their rôle in signalling and tumorigenesis involving the Fhit protein, the human fragile histidine triad protein, which is a novel Ap3A binding/cleaving protein. Dedicated to the memory of Professor Tsujiaki Hata, friend and associate for many years, who himself held a close interest in diadenosine and diguanosine polyphosphates.