Inhibition of Tumor Necrosis Factor Alpha (TNFα) Expression and Function In Vitro by Modified Antisense Oligonucleotides

Inhibition of Tumor Necrosis Factor Alpha (TNFα) Expression and Function In Vitro by Modified Antisense Oligonucleotides

Antisense oligonucleotides containing C-5 hexynyl/propynyl modified pyrimidines were synthesized using solid phase phosphoramidite chemistry. These modified oligonucleotides were found to have significant inhibitory activity against TNFα production in vitro.

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Veröffentlicht in:Nucleosides & nucleotides 1997-07, Vol.16 (7-9), p.1703-1707
Hauptverfasser: Ojwang, Joshua O., Rao, T. Sudhakar, Marshall, Hélène B., Mustain, Shawn D., Chaudhary, Nilabh, Walker, David A., Peyman, Anusch, Uhlmann, Eugen, Revankar, Ganapathi R., Rando, Robert F.
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Sprache:eng
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Zusammenfassung:Antisense oligonucleotides containing C-5 hexynyl/propynyl modified pyrimidines were synthesized using solid phase phosphoramidite chemistry. These modified oligonucleotides were found to have significant inhibitory activity against TNFα production in vitro.
ISSN:0732-8311
2332-3892
DOI:10.1080/07328319708006259