Derivatives of Imidazole-4-carboxamide as Substrates for Various DNA Polymerases

Derivatives of Imidazole-4-carboxamide as Substrates for Various DNA Polymerases

A series of nucleotide analogs bearing imidazole 4-carboxamides as bases were synthetized. The ability of Klenow fragment of pol I and HIV-1 reverse transcriptase to use these 5′-triphosphate derivatives as substrates in DNA elongation reactions was investigated.

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Veröffentlicht in:Nucleosides & nucleotides 1997-07, Vol.16 (7-9), p.1301-1302
Hauptverfasser: Le Bec, Christine, Roux, Pascal, Buc, Henri, Pochet, Sylvie
Format: Artikel
Sprache:eng
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Zusammenfassung:A series of nucleotide analogs bearing imidazole 4-carboxamides as bases were synthetized. The ability of Klenow fragment of pol I and HIV-1 reverse transcriptase to use these 5′-triphosphate derivatives as substrates in DNA elongation reactions was investigated.
ISSN:0732-8311
DOI:10.1080/07328319708006175