The Synthesis of the Sixteen Possible 2′-O-Methyl MMI Dimer Phosphoramidites: Building Blocks for the Synthesis of Novel Antisense Oligonucleotides

The Synthesis of the Sixteen Possible 2′-O-Methyl MMI Dimer Phosphoramidites: Building Blocks for the Synthesis of Novel Antisense Oligonucleotides

The synthesis of M ethylene( m ethylimino) or MMI linked nucleoside dimers in all sixteen possible configurations has been accomplished via a reductive coupling of a nucleosidic aldehyde with an hydroxylamine. This has allowed us to prepare all of the necessary 2′-O-methyl MMI dimer building blocks...

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Veröffentlicht in:Nucleosides & nucleotides 1997-07, Vol.16 (7-9), p.971-972
Hauptverfasser: Swayze, Eric E., Bhat, Balkrishen, Peoc'h, Didier, Sanghvi, Yogesh S.
Format: Artikel
Sprache:eng
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Zusammenfassung:The synthesis of M ethylene( m ethylimino) or MMI linked nucleoside dimers in all sixteen possible configurations has been accomplished via a reductive coupling of a nucleosidic aldehyde with an hydroxylamine. This has allowed us to prepare all of the necessary 2′-O-methyl MMI dimer building blocks necessary for use in an antisense motif.
ISSN:0732-8311
DOI:10.1080/07328319708006118