Synthesis and Evaluation Of 2″-Modified MMI Linked Dimers in Antisense Constructs

Synthesis and Evaluation Of 2″-Modified MMI Linked Dimers in Antisense Constructs

Synthesis of four methylene( m ethyl i mino) (MMI) linked dimers modifed at the 2′-position with fluoro and/or methoxy groups and their incorporation into different sequences has been accomplished. From these dimers, bis 2′-OMe MMI dimer was selected for further studies based on its synthetic access...

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Veröffentlicht in:Nucleosides & nucleotides 1997-07, Vol.16 (7-9), p.959-962
Hauptverfasser: Peoc'h, Didier, Swayze, Eric E., Bhat, Balkrishen, Dimock, Stuart, Griffey, Richard, Sanghvi, Yogesh S.
Format: Artikel
Sprache:eng
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Zusammenfassung:Synthesis of four methylene( m ethyl i mino) (MMI) linked dimers modifed at the 2′-position with fluoro and/or methoxy groups and their incorporation into different sequences has been accomplished. From these dimers, bis 2′-OMe MMI dimer was selected for further studies based on its synthetic accessibility, conformational study by NMR, and Tm analysis. Several chimeric antisense oligomers containing bis 2′-OMe dimers have been synthesized on a 10 μmol scale for in vivo studies.
ISSN:0732-8311
DOI:10.1080/07328319708006115