Synthesis of 8-Substituted Theophyllineβ-D-Ribofuranosides

Synthesis of 8-Substituted Theophyllineβ-D-Ribofuranosides

Methods for the synthesis of 8-chloro-and 8-bromotheophylline D-riboside triacetates by the chlorination of 7-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-theophylline with N-chlorosuccinimide or by the glycosylation of 8-bromotheophylline with 1,2,3,5-tetra-O-acetyl-β-D-ribofuranose were found. Nucleophi...

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Veröffentlicht in:Nucleosides & nucleotides 1993-09, Vol.12 (8), p.827-839
Hauptverfasser: Ozola, Vita, Ramzaeva, Natalya, Maurinsh, Yuris, Lidaks, Margeris
Format: Artikel
Sprache:eng
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Zusammenfassung:Methods for the synthesis of 8-chloro-and 8-bromotheophylline D-riboside triacetates by the chlorination of 7-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-theophylline with N-chlorosuccinimide or by the glycosylation of 8-bromotheophylline with 1,2,3,5-tetra-O-acetyl-β-D-ribofuranose were found. Nucleophilic displacement of the halogen gave 8-amino-, 8-alkylamino-, 8-benzylamino-, and 8-hydrazinotheophyllineβ-D-ribofuranosides.
ISSN:0732-8311
DOI:10.1080/07328319308018553