Straightforward Synthesis of 6-Thiodeoxyguanosine and Its Incorporation into Oligodeoxynucleotides

A convenient synthesis of 6-thiodeoxyguanosine from deoxyguanosine is described. Simple methods for incorporating 6-thiodeoxyguanosine into oligodeoxynucleotides are also given.

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Veröffentlicht in:Nucleosides & nucleotides 1992-06, Vol.11 (5), p.985-998
Hauptverfasser: Waters, Timothy R., Connolly, Bernard A.
Format: Artikel
Sprache:eng
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Zusammenfassung:A convenient synthesis of 6-thiodeoxyguanosine from deoxyguanosine is described. Simple methods for incorporating 6-thiodeoxyguanosine into oligodeoxynucleotides are also given.
ISSN:0732-8311
2332-3892
DOI:10.1080/07328319208021162