9-[2-(Phosphonomethoxy)alkoxy]purines, A New Series of Antiviral Acyclonucleotides

9-[2-(Phosphonomethoxy)alkoxy]purines, A New Series of Antiviral Acyclonucleotides

The synthesis and antiviral activities of a series of 9-[2-(phosphono-methoxy)alkoxy]purines are described. These compounds are the first reported acyclonucleotides in which a phosphonic acid bearing moiety is attached to N-9 of a purine via an N-0 bond. Some of them show potent activity against her...

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Veröffentlicht in:Nucleosides & nucleotides 1991-01, Vol.10 (1-3), p.427-430
Hauptverfasser: Duckworth, D. M., Harnden, M. R., Perkins, R. M., Planterose, D. N.
Format: Artikel
Sprache:eng
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Zusammenfassung:The synthesis and antiviral activities of a series of 9-[2-(phosphono-methoxy)alkoxy]purines are described. These compounds are the first reported acyclonucleotides in which a phosphonic acid bearing moiety is attached to N-9 of a purine via an N-0 bond. Some of them show potent activity against herpesviruses and others are potent and selective inhibitors of the replication of visna virus, a lentivirus.
ISSN:0732-8311
DOI:10.1080/07328319108046495