Anti-HIV Activity of the Antisense Oligonucleotides Bearing Lipophilic and Alkylating Groups at the 5′-Terminus

Anti-HIV Activity of the Antisense Oligonucleotides Bearing Lipophilic and Alkylating Groups at the 5′-Terminus

Experiments with the HIV-1 infected MT-4 cells evidence that coupling of lipophilic and alkylating groups to the antisense oligonucleotides improve their anti-HIV efficiency.

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Veröffentlicht in:Nucleosides & nucleotides 1991-01, Vol.10 (1-3), p.419-422
Hauptverfasser: Abramova, T. V., Blinov, V. M., Vlassov, V. V., Gorn, V. V., Zarytova, V. F., Ivanova, E. M., Konevets, D. A., Plyasunova, O. A., Pokrovsky, A. G., Sandahchiev, L. S., Svinarchuk, F. P., Starostin, V. P., Chapligina, S. R.
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Sprache:eng
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Zusammenfassung:Experiments with the HIV-1 infected MT-4 cells evidence that coupling of lipophilic and alkylating groups to the antisense oligonucleotides improve their anti-HIV efficiency.
ISSN:0732-8311
DOI:10.1080/07328319108046493