The Synthesis and Preliminary Biological Evaluations of Selected Analogues of the Potent Broad-Spectrum Antiviral Agent Ganciclovir 1′,3′-Cyclic Monophosphate1 (2′-Nor-cGMP)

The syntheses and antiviral activity of a series of analogues of the potent antiherpetic 2′-nor-cGMP are described. These derivatives contain systematic changes in either the heterocycle, the acyclic moiety, or the phosphate ring.