Synthesis of Some 2-Alkylated-5-Aminoimidazoles Related to Intermediates in Purine Nucleotide de novo and Thiamine Biosynthesis

Synthesis of Some 2-Alkylated-5-Aminoimidazoles Related to Intermediates in Purine Nucleotide de novo and Thiamine Biosynthesis

Routes to 2-alkylated-5-aminoimidazole nucleosides have been investigated in which the 2-substituent has up to 3 carbon atoms and capable of being interconverted into suitable oxy and 0x0 alkyl derivatives for use in enzyme inhibition and biochemical incorporation studies involving both purine nucle...

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Veröffentlicht in:Nucleosides & nucleotides 1989-01, Vol.8 (5-6), p.943-946
Hauptverfasser: Mackenzie, Grahame, Wilson, Hilary A., Humble, Robert W., Hewedi, Fawzy, Shaw, Gordon, Ewing, David
Format: Artikel
Sprache:eng
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Zusammenfassung:Routes to 2-alkylated-5-aminoimidazole nucleosides have been investigated in which the 2-substituent has up to 3 carbon atoms and capable of being interconverted into suitable oxy and 0x0 alkyl derivatives for use in enzyme inhibition and biochemical incorporation studies involving both purine nucleotide de novo and thiamine biosynthesis.
ISSN:0732-8311
1525-7770
DOI:10.1080/07328318908054250