Enzymatic Synthesis of P-Nitrophenyl β-Chitobioside

Enzymatic Synthesis of P-Nitrophenyl β-Chitobioside

p-Nitrophenyl β-chitobioside (2) was prepared from p-nitrophenyl 2-acetamido-2--deoxy-β-D-glucopyranoside (1) using β-N-acetylhexosaminidase from Aspergillus oryzae. As minor by-product a (1→6)-linked regioisomer (3a) was formed. Addition of (NH 4 ) 2 SO 4 and organic co-solvents (acetonitrile, diox...

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Veröffentlicht in:Journal of carbohydrate chemistry 1999-01, Vol.18 (8), p.975-984
Hauptverfasser: Kubisch, Jiří, Weignerová, Lenka, Kötter, Sven, Lindhorst, Thisbe K., Sedmera, Petr, Křen, Vladimír
Format: Artikel
Sprache:eng
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Zusammenfassung:p-Nitrophenyl β-chitobioside (2) was prepared from p-nitrophenyl 2-acetamido-2--deoxy-β-D-glucopyranoside (1) using β-N-acetylhexosaminidase from Aspergillus oryzae. As minor by-product a (1→6)-linked regioisomer (3a) was formed. Addition of (NH 4 ) 2 SO 4 and organic co-solvents (acetonitrile, dioxane) substantially increased the yield.
ISSN:0732-8303
1532-2327
DOI:10.1080/07328309908544047