Increased expression of CD23 in rheumatoid synovitis

Objective. Soluble (s)CD23 is a potent macrophage stimulator. High levels of this molecule have been reported in rheumatoid arthritis (RA) serum. We investigated the expression of CD23 and its ligands in rheumatoid synovial fluid and cells. Methods. Levels of sCD23, and cellular expression of CD23 a...

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Veröffentlicht in:	Scandinavian journal of rheumatology 2000, Vol.29 (3), p.154-159
Hauptverfasser:	HUISSOON, A. P, EMERY, P, BACON, P. A, GORDON, J, SALMON, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - metabolism Biological and medical sciences Diseases of the osteoarticular system Female Humans Inflammatory joint diseases Integrin alphaXbeta2 - metabolism Ligands Macrophage-1 Antigen - metabolism Macrophages - metabolism Male Medical sciences Middle Aged Receptors, Complement 3d - metabolism Receptors, IgE - metabolism Synovial Fluid - metabolism Synovitis - etiology Synovitis - metabolism
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Zusammenfassung:	Objective. Soluble (s)CD23 is a potent macrophage stimulator. High levels of this molecule have been reported in rheumatoid arthritis (RA) serum. We investigated the expression of CD23 and its ligands in rheumatoid synovial fluid and cells. Methods. Levels of sCD23, and cellular expression of CD23 and its ligands CD21, CD11b, and CD11c were measured in synovial fluid (SF) of RA patients and in blood of RA patients and controls. Results. SF contained higher levels of sCD23 than either rheumatoid or normal sera (median 4.8, 3.16,and 1.13 ng/ml respectively, p
ISSN:	0300-9742 1502-7732
DOI:	10.1080/030097400750002012