Effect of Some Design and Operating Variables in Preparative Gas Chromatography

The preparative gas-chromatography experiments described herein gave major variations in maximum production rates and maximum separable sample sizes as the result of changes in certain of the operating variables. The best results were realized by introducing the samples relatively slowly in the form of a rotary spray on the walls of an empty chamber vaporizer and by operating a packed inlet cone at least 60°C above the column temperature. Use of circulating air to thermostat the entire system gave much better results than when resistance wire windings were used to maintain the temperature of the column and associated equipment.