An HPLC Method for the Quantitative Determination of 1,4-Dihydroxy-5,8 Bis [[2-[(2-Hydroxyethyl) Amino] Ethyl] Amino] 9,10 - Anthracenedione (DHAQ, Lederle Labs CL232 315, NCS 301739) in Serum

An HPLC Method for the Quantitative Determination of 1,4-Dihydroxy-5,8 Bis [[2-[(2-Hydroxyethyl) Amino] Ethyl] Amino] 9,10 - Anthracenedione (DHAQ, Lederle Labs CL232 315, NCS 301739) in Serum

An HPLC method using reverse phase chromatography is presented for the quantitative determination of 1,4-Dihydroxy-5,8 Bis [[2-[(2-Hydroxyethyl) amino] ethyl] amino] 9,10 - anthracenedione in serum and urine at levels which are expected to be found in clinical trials of this drug.

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Veröffentlicht in:Journal of liquid chromatography 1980-01, Vol.3 (5), p.637-644
Hauptverfasser: Ostroy, Fred, Gams, Richard A.
Format: Artikel
Sprache:eng
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Zusammenfassung:An HPLC method using reverse phase chromatography is presented for the quantitative determination of 1,4-Dihydroxy-5,8 Bis [[2-[(2-Hydroxyethyl) amino] ethyl] amino] 9,10 - anthracenedione in serum and urine at levels which are expected to be found in clinical trials of this drug.
ISSN:0148-3919
DOI:10.1080/01483918008060179