Synthesis and Equilibrium Studies of the Metal Complexes of 4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)-benzenesulfonamide (Sulphadimidine)

The formation equilibria of the complexes of some transition metal ions with sulphadimidine (SDD) have been investigated by a potentiometric technique. The stepwise formation constants of the complexes formed in solution were calculated using the non-linear least-squares computer program MINIQUAD. The concentration distribution of the complex species was determined. Complexes of Cu(II), Cr(II), Ni(II), Co(II), Zn(II), Hg(II), Cd(II), UO 2 (VI) and Pd(II) have been synthesized and characterized by elemental analyses, electrolytic conductance, electronic, IR, 1 H NMR, and mass spectra and thermogravimetric studies. The ligand forms 1:1 complexes (metalion: ligand) with Cu(II), Zn(II), Hg(II), Cd(II), UO 2 (VI) and Pd(II) and 1:2 complexes with Cr(III), Ni(II) and Co(II). Referee I: P. R. Singh Referee II: F. R. Johnston