Synthesis of 2,4-Diamino-5-Cinnamoylthiazoles and Their Attempted Cyclization

Synthesis of 2,4-Diamino-5-Cinnamoylthiazoles and Their Attempted Cyclization

Synthesis of 4-amino-2-aryl(or alkyl)amino-5-cinnamoylthiazoles by a [(C ─ N ─ C ─ S) + C] ring construction route is reported. Unlike the analogous 2′-aminochalcones, neither do these thiazoles cyclize to bicyclic pyridones, nor could these be prepared from the corresponding 5-acetylthiazoles and b...

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Veröffentlicht in:Synthetic communications 1998-10, Vol.28 (19), p.3625-3632
Hauptverfasser: Binu, R, Deepa, S, N.Rajasekharan, K.
Format: Artikel
Sprache:eng
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Zusammenfassung:Synthesis of 4-amino-2-aryl(or alkyl)amino-5-cinnamoylthiazoles by a [(C ─ N ─ C ─ S) + C] ring construction route is reported. Unlike the analogous 2′-aminochalcones, neither do these thiazoles cyclize to bicyclic pyridones, nor could these be prepared from the corresponding 5-acetylthiazoles and benzaldehyde.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919808004909