One Pot Synthesis of Oxazolidinones by Tosylation or Mesylation of N-Boc-β-Amino Alcohols

One Pot Synthesis of Oxazolidinones by Tosylation or Mesylation of N-Boc-β-Amino Alcohols

Oxazolidinones have been synthesized from the reaction of N-Boc derivatives of β-amino alcohols with TsCl or MsCl. Basic reaction condition is not necessary to the formation of oxazolidinone from the tosylated intermediate. On the other hand, oxazolidinone was produced from N-Boc derivative of β-ami...

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Veröffentlicht in:Synthetic communications 1996-01, Vol.26 (1), p.83-88
Hauptverfasser: Lee, Jae Wook, Lee, Jae Ho, Son, Ho Jung, Choi, Young Key, Yoon, Geal Jung, Park, Myung Hwan
Format: Artikel
Sprache:eng
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Zusammenfassung:Oxazolidinones have been synthesized from the reaction of N-Boc derivatives of β-amino alcohols with TsCl or MsCl. Basic reaction condition is not necessary to the formation of oxazolidinone from the tosylated intermediate. On the other hand, oxazolidinone was produced from N-Boc derivative of β-amino alcohol under NaH.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919608003865