Improved Large-Scale Preparation of 4-Iodopicolinic Acid

Improved Large-Scale Preparation of 4-Iodopicolinic Acid

Dimethylformamide showed a dramatic catalytic effect in the chlorination of picolinic acid with thionyl chloride. Methyl 4-chloropicolinate was directly transformed to 4-iodopicolinic acid in a good yield.

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Veröffentlicht in:Synthetic communications 1996-05, Vol.26 (10), p.2017-2025
1. Verfasser: Lohse, Olivier
Format: Artikel
Sprache:eng
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Beschreibung
Zusammenfassung:Dimethylformamide showed a dramatic catalytic effect in the chlorination of picolinic acid with thionyl chloride. Methyl 4-chloropicolinate was directly transformed to 4-iodopicolinic acid in a good yield.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919608003557