Easy Synthesis of Unnatural Siderophores

Easy Synthesis of Unnatural Siderophores

N-Acetyl-N-benzyloxy-β-alanine was obtained by Michael addition of N-acetyl-N-benzyloxyamine on terbutylacrylate under solvent-free PTC conditions followed by elimination of the terbutyl group. Polyamines were acylated with N-acetyl-N-benzyloxy-β-alanine. The prepared compounds exhibited a moderate...

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Veröffentlicht in:Synthetic communications 1995-09, Vol.25 (17), p.2515-2519
Hauptverfasser: Zhu, J., Robin, S., Goasdoué, N., Goasdoué, C., Loupy, A., Galons, H.
Format: Artikel
Sprache:eng
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Zusammenfassung:N-Acetyl-N-benzyloxy-β-alanine was obtained by Michael addition of N-acetyl-N-benzyloxyamine on terbutylacrylate under solvent-free PTC conditions followed by elimination of the terbutyl group. Polyamines were acylated with N-acetyl-N-benzyloxy-β-alanine. The prepared compounds exhibited a moderate activity against HIV protease.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919508011794