Stereospecific Syntheses of Clomiphene and Tamoxifen via Stannylcupration of Diphenylacetylene

Stereospecific Syntheses of Clomiphene and Tamoxifen via Stannylcupration of Diphenylacetylene

Stereospecific trans-stannylcupration of diphenylacetylene affords a 1,2-dimetallostilbene which may be elaborated into either Clomiphene or Tamoxifen through palladium-catalyzed coupling with an aryl iodide.

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Bibliographische Detailangaben
Veröffentlicht in:Synthetic communications 1995-12, Vol.25 (24), p.4071-4079
1. Verfasser: Cummins, Clark H.
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:Stereospecific trans-stannylcupration of diphenylacetylene affords a 1,2-dimetallostilbene which may be elaborated into either Clomiphene or Tamoxifen through palladium-catalyzed coupling with an aryl iodide.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919508011484