The Preparation of Substituted 3,4-Dihydro-1H-2-benzopyran-1-ones from the Dianions of Ortho-Toluic Acids

The Preparation of Substituted 3,4-Dihydro-1H-2-benzopyran-1-ones from the Dianions of Ortho-Toluic Acids

The dianions of ortho-toluic and α-phenyl-ortho-toluic acids were prepared with lithium diisopropylamide (LDA), condensed with certain aldehydes or ketones, and the resulting intermediates were acid-cyclized to substituted 3,4-dihydro-1H-2-benzopyran-1-ones (dihydroisocoumarins).

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Veröffentlicht in:Synthetic communications 1994-03, Vol.24 (6), p.779-788
Hauptverfasser: Hildebran, Karen C., Cordray, Tracy L., Chan, Kam W., Beam, Charles F.
Format: Artikel
Sprache:eng
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Zusammenfassung:The dianions of ortho-toluic and α-phenyl-ortho-toluic acids were prepared with lithium diisopropylamide (LDA), condensed with certain aldehydes or ketones, and the resulting intermediates were acid-cyclized to substituted 3,4-dihydro-1H-2-benzopyran-1-ones (dihydroisocoumarins).
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919408011300