A New Synthesis of the Potent 5-HT1 Receptor Ligand, 5-Carboxyamidotryptamine (5-CT)

A New Synthesis of the Potent 5-HT1 Receptor Ligand, 5-Carboxyamidotryptamine (5-CT)

A short, convenient and relatively efficient synthesis of 5-CT is developed through a modified Michael reaction. This method represents a new general synthesis for tryptamines with labile indole substituents.

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Veröffentlicht in:Synthetic communications 1993-04, Vol.23 (8), p.1101-1110
Hauptverfasser: Agarwal, Atul, Jalluri, R. K., Blanton, C. DeWitt, Taylor, E. Will
Format: Artikel
Sprache:eng
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Zusammenfassung:A short, convenient and relatively efficient synthesis of 5-CT is developed through a modified Michael reaction. This method represents a new general synthesis for tryptamines with labile indole substituents.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919308018587