Regioselective N-Alkylation of Methyl Indole-2-carboxylate

Regioselective N-Alkylation of Methyl Indole-2-carboxylate

Only N-alkylated roducts were obtained by reacting functionalized halides with methyl indole-Zcarboxylate using potassium carbonate in acetonitrile or sodium hydride in dimethylformamide. Ethyl acrylate also gave rise to N-alkylation.

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Veröffentlicht in:Synthetic communications 1993-07, Vol.23 (13), p.1813-1820
Hauptverfasser: Mérour, J. Y., Cossais, F.
Format: Artikel
Sprache:eng
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Zusammenfassung:Only N-alkylated roducts were obtained by reacting functionalized halides with methyl indole-Zcarboxylate using potassium carbonate in acetonitrile or sodium hydride in dimethylformamide. Ethyl acrylate also gave rise to N-alkylation.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919308011281