Lead Tetraacetate Cleavage of Chiral Phenylglycinol Derived Secondary Amines Without Racemization

Lead Tetraacetate Cleavage of Chiral Phenylglycinol Derived Secondary Amines Without Racemization

Diastereomerically enriched N-(1,1-disubstituted methyl)(2 '-hydroxyl'-phenylethyl) amines were oxidatively converted to enantiomerically enriched primary disubstituted methylamines in excellent yields without racemization, using an improved lead tetraacerate (LTA) procedure.

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Veröffentlicht in:Synthetic communications 1993-07, Vol.23 (14), p.2055-2064
Hauptverfasser: Mokhallalati, Mohamed K., Pridgen, Lendon N.
Format: Artikel
Sprache:eng
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Zusammenfassung:Diastereomerically enriched N-(1,1-disubstituted methyl)(2 '-hydroxyl'-phenylethyl) amines were oxidatively converted to enantiomerically enriched primary disubstituted methylamines in excellent yields without racemization, using an improved lead tetraacerate (LTA) procedure.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919308009866