Spectral Studies on the Interaction of Ru(phen)2(dppx)2+ (phen=1.10-phenanthroline, dppx=7,8-dimethyldipyrido [3,2-a:2′,3′-c] phenazine) and DNA

The interaction of Ru(phen) 2 (dppx) 2+ (phen=1.10-phenanthroline, dppx=7,8-dimethyl dipyrido[3,2-a:2′,3′-c]phenazine) and the calf thymus DNA were studied with fluorescence and ultraviolet visible absorption spectroscopy. Fe(CN) 6 4 and NaCl can not quench the fluorescence of Ru(phen) 2 (dppx) 2+ -DNA. which indicate that Ru(phen) 2 (dppx) 2+ intercalate into the double helix of DNA. The ultraviolet visible absorption spectrum of Ru(phen) 2 (dppx) 2+ calf thymus DNA, and the results of their interaction reveal that Ru(phen) 2 (dppx) 2+ intercalate into the double helix of DNA via the ligand dppx.