NMR Studies of Drugs. Methaqualone. Approaches to Rigorous 1H and 13C Assignments with Applications of Achiral and Chiral Shift Reagents

The 1 H and 13 C NMR spectra of methaqualone, 1 , have been extensively studied using one and two-dimensional techniques. These 300 MHz 1 H and 75 MHz 13 C studies have allowed rigorous assignments to be made for the methyl groups and the quinazolinone nucleus. The 60 MHz 1 H spectra for 1 in CDCl 3 have been examined with