Influence of chemotherapy courses on the rate of bloodstream infections during neutropenia in adult acute myeloid leukaemia

To evaluate the effect of various chemotherapy courses on the rate of bloodstream infections (BSI) during therapy-related neutropenia, all infection episodes of adult patients with acute myeloid leukaemia (AML) during 7 y were retrospectively analysed in a university hospital. Of the 182 infection e...

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Veröffentlicht in:	Scandinavian journal of infectious diseases 2008, Vol.40 (8), p.642-647
Hauptverfasser:	Kinnunen, Urpo, Koistinen, Pirjo, Ohtonen, Pasi, Koskela, Markku, Syrjälä, Hannu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bacteremia - epidemiology Bacteremia - etiology Bacterial diseases Bacterial sepsis Biological and medical sciences Female Flow Cytometry Fungemia - epidemiology Fungemia - etiology Gram-Negative Bacteria - isolation & purification Gram-Positive Bacteria - isolation & purification Hematologic and hematopoietic diseases Human bacterial diseases Humans Infectious diseases Leukemia, Myeloid, Acute - complications Leukemia, Myeloid, Acute - drug therapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Neutropenia - chemically induced Other diseases. Hematologic involvement in other diseases Statistics, Nonparametric Yeasts - isolation & purification Young Adult
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Zusammenfassung:	To evaluate the effect of various chemotherapy courses on the rate of bloodstream infections (BSI) during therapy-related neutropenia, all infection episodes of adult patients with acute myeloid leukaemia (AML) during 7 y were retrospectively analysed in a university hospital. Of the 182 infection episodes in 76 AML patients, 37% (n=68) were BSI. The risk ratio (RR) of BSI was highest after regimens containing high-dose cytarabine (2.4 with 95% confidence interval (CI) 1.3-4.4) and lowest after thioguanine-containing courses (RR: 0.2, 95% CI 0.2-0.5). Chemotherapy courses per se may have an influence on the rate of BSI during neutropenia.
ISSN:	0036-5548 1651-1980
DOI:	10.1080/00365540801947338