DNA sequence-based detection of group B Streptococcus directly from heart valve tissue in a patient with culture-negative endocarditis

DNA sequence-based detection of group B Streptococcus directly from heart valve tissue in a patient with culture-negative endocarditis

A human case of culture-negative bacterial endocarditis is presented where conventional methods failed to determine a microbial aetiology. DNA sequencing performed directly on autopsy heart valve tissue revealed Streptococcus agalactiae (group B streptococcus). To our knowledge, this is the first re...

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Veröffentlicht in:Scandinavian Journal of Infectious Diseases 2006, Vol.38 (10), p.931-934
Hauptverfasser: Guggisberg, Kelly, Parker, Robin, Megran, David, Zhang, Kunyan, Lester, Wanda, Elsayed, Sameer
Format: Report
Sprache:eng
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Zusammenfassung:A human case of culture-negative bacterial endocarditis is presented where conventional methods failed to determine a microbial aetiology. DNA sequencing performed directly on autopsy heart valve tissue revealed Streptococcus agalactiae (group B streptococcus). To our knowledge, this is the first report of DNA sequence-based detection of this organism directly from a heart valve.
ISSN:0036-5548
1651-1980
DOI:10.1080/00365540600561793