Comparison of Indomethacin and Nimesulide, a Selective Cyclooxygenase-2 Inhibitor, on Key Pathophysiologic Steps in the Pathogenesis of Nonsteroidal Anti-Inflammatory Drug Enteropathy in the Rat

Comparison of Indomethacin and Nimesulide, a Selective Cyclooxygenase-2 Inhibitor, on Key Pathophysiologic Steps in the Pathogenesis of Nonsteroidal Anti-Inflammatory Drug Enteropathy in the Rat

Background: The predicted gastrointestinal tolerability of specific cyclooxygenase-2 inhibitors could be due to either a lack of 'topical' irritation and/or lack of effect on cyclooxygenase-1. Methods: Key pathophysiologic steps (in vitro and in vivo uncoupling, intestinal prostanoid level...

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Veröffentlicht in:Scandinavian journal of gastroenterology 1998, Vol.33 (7), p.728-735
Hauptverfasser: SIGTHORSSON, G, JACOB, M, BJARNASON, I, WRIGGLESWORTH, J, SOMASUNDARAM, S, TAVARES, I, FOSTER, R, ROSETH, A, RAFI, S, MAHMUD, T, SIMPSON, R
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Anti-Inflammatory Agents, Non-Steroidal - toxicity
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Cell Membrane Permeability - drug effects
Cyclooxygenase Inhibitors - toxicity
Disease Models, Animal
Dose-Response Relationship, Drug
Feces - chemistry
Indomethacin - toxicity
Intestinal Diseases - chemically induced
Intestinal Diseases - metabolism
Intestinal Mucosa - drug effects
Intestinal Mucosa - metabolism
Male
Medical sciences
Microscopy, Electron
Mitochondria - drug effects
Mitochondria - ultrastructure
Oxygen Consumption - drug effects
Pharmacology. Drug treatments
Prostaglandins - analysis
Prostaglandins - biosynthesis
Rats
Rats, Sprague-Dawley
Reference Values
Statistics, Nonparametric
Sulfonamides - toxicity
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Zusammenfassung:Background: The predicted gastrointestinal tolerability of specific cyclooxygenase-2 inhibitors could be due to either a lack of 'topical' irritation and/or lack of effect on cyclooxygenase-1. Methods: Key pathophysiologic steps (in vitro and in vivo uncoupling, intestinal prostanoid levels (prostaglandin E, thromboxane B
ISSN:0036-5521
1502-7708
DOI:10.1080/00365529850171675