Obesity Increases the Severity of Acute Experimental Pancreatitis in the Rat

Background: Studies in patients with acute pancreatitis have shown a correlation between obesity and serious complications or a fatal outcome. However, the mechanisms by which obesity aggravates acute pancreatitis are not known. In the present study we used the sodium taurocholate model of pancreati...

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Veröffentlicht in:	Scandinavian journal of gastroenterology 2001-01, Vol.36 (6), p.658-663
Hauptverfasser:	SEGERSVÄRD, R, SYLVAN, M, HERRINGTON, M, LARSSON, J, PERMERT, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Necrotizing Pancreatitis Animal Dietary Fats Fat Necrosis Fatty Liver Mortality Obesity Pancreas Rats Triglycerides Animals Biological and medical sciences Dietary Fats - administration & dosage Gastroenterology. Liver. Pancreas. Abdomen Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Obesity - complications Obesity - genetics Obesity - physiopathology Other diseases. Semiology Pancreatitis, Acute Necrotizing - chemically induced Pancreatitis, Acute Necrotizing - physiopathology Rats Rats, Zucker Taurocholic Acid
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Zusammenfassung:	Background: Studies in patients with acute pancreatitis have shown a correlation between obesity and serious complications or a fatal outcome. However, the mechanisms by which obesity aggravates acute pancreatitis are not known. In the present study we used the sodium taurocholate model of pancreatitis to examine the effect of obesity on severity and outcome in acute experimental pancreatitis (AEP). Methods:
ISSN:	0036-5521 1502-7708
DOI:	10.1080/00365520120639