Analysis of Pheniramine Naleate and Cblorpheniramine Maleate Via Their Fe (III) Cohplexes

A new spectrophotoraetric method has been developed for the analysis of pheniramine maleate and chlorphenlramine maleste, based on their reaction with iron (III). Pheniramine maleate and ch lor pheniramine maleate were found to form a 2:1 complex with iron (III) with an average log. stability constant of 12.26 and 12.36, respectively. The iron (III) complexes of both drugs showed maximum absorption at 273 nm, at pH 5, with slopes equal to 0.710 and 0.898 for pheniramine maleate complex and chlorpheniramine maleate complex, respectively. The proposed method was used for the determination of pheniramine maleate and chlorpheniramine maleate in quantities ranging between 0.25 × 10 −4 M to 2.5 × 10 −4 M with mean percentage recoveries of 100.17 ± 1.09% and 100.00 ± 1.13% for both drugs, respectively. The results obtained were compared with that of the B.P. (1980) method.