A Sensitive Gas Chromatographic Method for the Determination of Metoprolol in Human Plasma

A sensitive method for the determination of metoprolol in plasma has been developed. The procedure is based on gas chromatographic measurements of derivatized metoprolol, using 9-bromophenanthrene as internal standard. Metoprolol is derivatized with pentafluoropropionic anhydride. The resulting deri...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Analytical letters 1980-01, Vol.13 (15), p.1359-1371
Hauptverfasser:	Zak, Sylvia, Honc, Frank, Gilleran, Thomas G.
Format:	Artikel
Sprache:	eng
Schlagworte:	gas chromatographic assay Metoprolol plasma assay pentafluoropropionic acid derivative
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A sensitive method for the determination of metoprolol in plasma has been developed. The procedure is based on gas chromatographic measurements of derivatized metoprolol, using 9-bromophenanthrene as internal standard. Metoprolol is derivatized with pentafluoropropionic anhydride. The resulting derivative gives a four-fold increase in sensitivity compared to the published methods where trifluoroacetic anhydride was used for derivatization.
ISSN:	0003-2719 1532-236X
DOI:	10.1080/00032718008081372