No effect of systemic administration of somatomedin C on bone repair in rats

The effect of somatomedin C on the bone repair process was studied in a rat femoral osteotomy. We used continuous systemic administration of human recombinant somatomedin C (110 μg/100 g per day). Radiographic evaluation after 4 weeks showed no effect of somatomedin C on the healing. There was no ef...

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Veröffentlicht in:	Acta orthopaedica 1990, Vol.61 (4), p.335-338
Hauptverfasser:	Kirkeby, Ole J., Ekeland, Arne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bone and Bones - drug effects Bone and Bones - physiology Bones, joints and connective tissue. Antiinflammatory agents Femur - diagnostic imaging Femur - drug effects Femur - physiology Femur - surgery Insulin-Like Growth Factor I - pharmacology Male Medical sciences Osteotomy Pharmacology. Drug treatments Radiography Rats Rats, Inbred Strains Recombinant Proteins Somatomedins - pharmacology Wound Healing - drug effects
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Zusammenfassung:	The effect of somatomedin C on the bone repair process was studied in a rat femoral osteotomy. We used continuous systemic administration of human recombinant somatomedin C (110 μg/100 g per day). Radiographic evaluation after 4 weeks showed no effect of somatomedin C on the healing. There was no effect on mechanical strength, and no effect was found on callus vascularization or mineralization. The weight of the callus was slightly reduced in the somatomedin C treated rats. The results were not suggestive of any acceleration with systemic somatomedin C treatment in the early phase of cortical bone repair.
ISSN:	1745-3674 0001-6470 1745-3682
DOI:	10.3109/17453679008993530