Folinic Acid Rescue for Vincristine Toxicity
Inadvertent vincristine sulfate overdosage was treated with folinic acid. The sequence of development of the signs and symptoms associated with known vincristine toxicity was accentuated; however, the duration of these toxicities was markedly compressed in time when compared with previous reports. T...
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| Veröffentlicht in: | Clinical toxicology 1979, Vol.14 (1), p.71-78 |
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| container_title | Clinical toxicology |
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| creator | Grush, Owen C. Morgan, Samuel K. |
| description | Inadvertent vincristine sulfate overdosage was treated with folinic acid. The sequence of development of the signs and symptoms associated with known vincristine toxicity was accentuated; however, the duration of these toxicities was markedly compressed in time when compared with previous reports. The known pharmacologic and biologic activities of vincristine sulfate and presumed mechanism of counteractivity of folinic acid is presented. |
| doi_str_mv | 10.3109/15563657909030115 |
| format | Article |
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The sequence of development of the signs and symptoms associated with known vincristine toxicity was accentuated; however, the duration of these toxicities was markedly compressed in time when compared with previous reports. The known pharmacologic and biologic activities of vincristine sulfate and presumed mechanism of counteractivity of folinic acid is presented.</description><identifier>ISSN: 1556-3650</identifier><identifier>ISSN: 0009-9309</identifier><identifier>EISSN: 1556-9519</identifier><identifier>DOI: 10.3109/15563657909030115</identifier><identifier>PMID: 312178</identifier><language>eng</language><publisher>United States: Informa UK Ltd</publisher><subject>Adolescent ; Antidotes ; Humans ; Leucovorin - pharmacology ; Leucovorin - therapeutic use ; Male ; Medication Errors ; Time Factors ; Vincristine - antagonists & inhibitors ; Vincristine - pharmacology ; Vincristine - poisoning</subject><ispartof>Clinical toxicology, 1979, Vol.14 (1), p.71-78</ispartof><rights>1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1979</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-3a73b1ead46547a7eda55d7d986f8a0e1e57a9e8275387b1aaf822b78f2181db3</citedby><cites>FETCH-LOGICAL-c400t-3a73b1ead46547a7eda55d7d986f8a0e1e57a9e8275387b1aaf822b78f2181db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/15563657909030115$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/15563657909030115$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,60436,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/312178$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grush, Owen C.</creatorcontrib><creatorcontrib>Morgan, Samuel K.</creatorcontrib><title>Folinic Acid Rescue for Vincristine Toxicity</title><title>Clinical toxicology</title><addtitle>Clin Toxicol</addtitle><description>Inadvertent vincristine sulfate overdosage was treated with folinic acid. The sequence of development of the signs and symptoms associated with known vincristine toxicity was accentuated; however, the duration of these toxicities was markedly compressed in time when compared with previous reports. The known pharmacologic and biologic activities of vincristine sulfate and presumed mechanism of counteractivity of folinic acid is presented.</description><subject>Adolescent</subject><subject>Antidotes</subject><subject>Humans</subject><subject>Leucovorin - pharmacology</subject><subject>Leucovorin - therapeutic use</subject><subject>Male</subject><subject>Medication Errors</subject><subject>Time Factors</subject><subject>Vincristine - antagonists & inhibitors</subject><subject>Vincristine - pharmacology</subject><subject>Vincristine - poisoning</subject><issn>1556-3650</issn><issn>0009-9309</issn><issn>1556-9519</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kG9LwzAQxoP4b04_gOCLfgCruaZpEvTNGE6FgSDTt-WapCyja0fSofv2tnQIIvrqjnvu93DPEXIJ9IYBVbfAecYyLhRVlFEAfkBG_SxWHNThvu8W6Ck5C2FFKZOpghNyzCABIUfketZUrnY6mmhnolcb9NZGZeOjd1dr70Lrahstmk-nXbs7J0clVsFe7OuYvM0eFtOneP7y-DydzGOdUtrGDAUrwKJJM54KFNYg50YYJbNSIrVguUBlZSI4k6IAxFImSSFkmYAEU7AxgcFX-yYEb8t8490a_S4Hmve581-5O-ZqYDbbYm3NNzEE7eT7QXZ1l26NH42vTN7irmp86bHWLvTOf7vf_cCXFqt2qdHbfNVsfd1945_bvgAudnbo</recordid><startdate>1979</startdate><enddate>1979</enddate><creator>Grush, Owen C.</creator><creator>Morgan, Samuel K.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1979</creationdate><title>Folinic Acid Rescue for Vincristine Toxicity</title><author>Grush, Owen C. ; Morgan, Samuel K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-3a73b1ead46547a7eda55d7d986f8a0e1e57a9e8275387b1aaf822b78f2181db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Adolescent</topic><topic>Antidotes</topic><topic>Humans</topic><topic>Leucovorin - pharmacology</topic><topic>Leucovorin - therapeutic use</topic><topic>Male</topic><topic>Medication Errors</topic><topic>Time Factors</topic><topic>Vincristine - antagonists & inhibitors</topic><topic>Vincristine - pharmacology</topic><topic>Vincristine - poisoning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grush, Owen C.</creatorcontrib><creatorcontrib>Morgan, Samuel K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Clinical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grush, Owen C.</au><au>Morgan, Samuel K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Folinic Acid Rescue for Vincristine Toxicity</atitle><jtitle>Clinical toxicology</jtitle><addtitle>Clin Toxicol</addtitle><date>1979</date><risdate>1979</risdate><volume>14</volume><issue>1</issue><spage>71</spage><epage>78</epage><pages>71-78</pages><issn>1556-3650</issn><issn>0009-9309</issn><eissn>1556-9519</eissn><abstract>Inadvertent vincristine sulfate overdosage was treated with folinic acid. The sequence of development of the signs and symptoms associated with known vincristine toxicity was accentuated; however, the duration of these toxicities was markedly compressed in time when compared with previous reports. The known pharmacologic and biologic activities of vincristine sulfate and presumed mechanism of counteractivity of folinic acid is presented.</abstract><cop>United States</cop><pub>Informa UK Ltd</pub><pmid>312178</pmid><doi>10.3109/15563657909030115</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1556-3650 |
| ispartof | Clinical toxicology, 1979, Vol.14 (1), p.71-78 |
| issn | 1556-3650 0009-9309 1556-9519 |
| language | eng |
| recordid | cdi_informahealthcare_journals_10_3109_15563657909030115 |
| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Adolescent Antidotes Humans Leucovorin - pharmacology Leucovorin - therapeutic use Male Medication Errors Time Factors Vincristine - antagonists & inhibitors Vincristine - pharmacology Vincristine - poisoning |
| title | Folinic Acid Rescue for Vincristine Toxicity |
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