Folinic Acid Rescue for Vincristine Toxicity

Folinic Acid Rescue for Vincristine Toxicity

Inadvertent vincristine sulfate overdosage was treated with folinic acid. The sequence of development of the signs and symptoms associated with known vincristine toxicity was accentuated; however, the duration of these toxicities was markedly compressed in time when compared with previous reports. T...

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Veröffentlicht in:Clinical toxicology 1979, Vol.14 (1), p.71-78
Hauptverfasser: Grush, Owen C., Morgan, Samuel K.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Antidotes
Humans
Leucovorin - pharmacology
Leucovorin - therapeutic use
Male
Medication Errors
Time Factors
Vincristine - antagonists & inhibitors
Vincristine - pharmacology
Vincristine - poisoning
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Zusammenfassung:Inadvertent vincristine sulfate overdosage was treated with folinic acid. The sequence of development of the signs and symptoms associated with known vincristine toxicity was accentuated; however, the duration of these toxicities was markedly compressed in time when compared with previous reports. The known pharmacologic and biologic activities of vincristine sulfate and presumed mechanism of counteractivity of folinic acid is presented.
ISSN:1556-3650
0009-9309
1556-9519
DOI:10.3109/15563657909030115