Synthesis and the Antiperoxidase Activity of Seleno Analogues of the Antithyroid Drug Propylthiouracil

Abstract The synthesis of 6-n-propyl-2-selenouracil (PSeU, Ib) and its methyl derivative (MSeU, Ic) are described. Replacement of the sulfur atom at C2 by selenium increased with antiperoxidase activity of these analogues five fold when compared to the clinically used antithyroid drug propylthiourac...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of enzyme inhibition 1993, Vol.7 (2), p.147-150
Hauptverfasser:	Aboul-Enein, Hassan Y., Awad, Amin A., Al-Andis, Naser M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antiperoxidase activity antithyroid activity Biological and medical sciences Hormones. Endocrine system Medical sciences Peroxidases - antagonists & inhibitors Pharmacology. Drug treatments Propylthiouracil - analogs & derivatives Propylthiouracil - pharmacology Selenium Compounds - chemical synthesis Selenium Compounds - pharmacology Seleno analogues of propylthiouracil Structure-Activity Relationship structure-activity relationships Swine Thyroid Gland - drug effects Thyroid Gland - enzymology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Abstract The synthesis of 6-n-propyl-2-selenouracil (PSeU, Ib) and its methyl derivative (MSeU, Ic) are described. Replacement of the sulfur atom at C2 by selenium increased with antiperoxidase activity of these analogues five fold when compared to the clinically used antithyroid drug propylthiouracil (PTU). The structure-activity relationships of these agents are discussed.
ISSN:	1475-6366 8755-5093 1475-6374 1029-2462
DOI:	10.3109/14756369309040756