Liposomal Amphotericin B Bases of Therapeutic Index Increase

Liposomes represent for amphotericin B (AmB) a promising delivery system that may reduce (he important toxicity of the drug. Liposomal AmB has a higher therapeutic index than AmB alone and allows to use larger doses. The mechanism of reduced toxicity may be related to a better targeting ability, a protective effect, and a selective transfer of liposomes. Anyway the liposomes intercalated AmB tends to be uptaken by organs that belong to the reticuloendothelial system, where fungi, the target cells, are localized.