Dissolution Characteristics of Ibuprofen: Phospholipidcoprecipitates

Abstract Ibuprofen powders were blended with phospholipids to prepare physical mixtures or made into solid dispersions by the solvent method and their comparative dissolution profiles were studied. Ibuprofen exhibited significantly improved dissolution rates in phospholipid coprecipitates compared to either physical mixtures or the pure ibuprofen. the coprecipitates of phospholipid-ibuprofen were made at 1:10, 1:20, 1:30 and 1:40 ratios and dissolution profiles were monitored up to 90 minutes. Marginal increase in dissolution rates were observed by increasing the phosopholipid-ibuprofen ratio from 1:40 to 1:20 and further increase to 1:10 ratio did not produce any difference. the coprecipitates of phosopholipid-ibuprofen at a 1:20 ratio showed more than 2 fold increase in the total amount dissolved in water after 90 minutes compared to ibuprofen alone. No significant difference was observed among the three phospholipids in terms of enhancing dissolution rate of ibuprofen in water. When studies were conducted with 1:20 phospholipid-ibuprofen at pH 2.2 medium, the total amount dissolved in water after 90 minutes varied significantly among the phospholipids studied. DSPC showed best results followed by DPPC and DMPC respectively.