Enzymatic Resolutions of Heterocyclic Alcohols

Enzymatic Resolutions of Heterocyclic Alcohols

The butyrates and acetates of heterocyclic alcohols like 3 - hydroxy tetrahydrofuran and - pyran, 3- and 4 - chromanol as well as the corresponding sulfur heterocycles were hydrolyzed using lipase from Candida rugosa (CRL) and from Pseudomonas cepacia, (PCL). Poor to excellent enantioselectivities w...

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Veröffentlicht in:Biocatalysis 1994, Vol.9 (1-4), p.61-69
Hauptverfasser: Honig, Helmut, Shi, Nongyuan, Polanz, Gerald
Format: Artikel
Sprache:eng
Schlagworte:
Candida rugosa
enantioselective hydrolysis
enantioselective transesterification
heterocyclic alcohol
lipase
Pseudomonas cepacia
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Zusammenfassung:The butyrates and acetates of heterocyclic alcohols like 3 - hydroxy tetrahydrofuran and - pyran, 3- and 4 - chromanol as well as the corresponding sulfur heterocycles were hydrolyzed using lipase from Candida rugosa (CRL) and from Pseudomonas cepacia, (PCL). Poor to excellent enantioselectivities were obtained depending on the structure of the substrates. An electrostatic amendment to the steric substrate model for PGL is proposed.
ISSN:1024-2422
0886-4454
1029-2446
DOI:10.3109/10242429408992107