Success in inducing ovulation in a case of premature ovarian failure using growth hormone-releasing hormone

Ovulation was obtained in a 29-year-old woman affected by premature ovarian failure who had previously failed to respond to two attempts performed administrating human menopausal gonadotropin or follicle-stimulating hormone after the spontaneous gonadotropin production was suppressed using a gonadotropin-releasing hormone analog (buserlin). Induction of ovulation succeeded when 1000 mg/day growth hormone-releasing hormone was added to the induction scheme. Five mature follicles were obtained after 27 days therapy and the serum level of 17β-cstradiol was 975 pg/ml (195 pg/ml per follicle) at the time of human chronic gonadotropin administration.