Hair Dye Related Acute Kidney Injury - A Clinical and Experimental Study

Hair Dye Related Acute Kidney Injury - A Clinical and Experimental Study

We studied paraphenylenediamine (PPD)-related acute kidney injury (AKI) in 81 patients and also in albino rats experimentally. In the patients' group AKI was found in 32.7%. Of them, 81.4% needed dialysis support. The overall mortality was 25.9%. In experimental rats the renal lesions were note...

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Veröffentlicht in:Renal failure 2012-08, Vol.34 (7), p.880-884
Hauptverfasser: Sandeep Reddy, Yanala, Abbdul Nabi, Shaik, Apparao, Chippada, Srilatha, Chinthamaneni, Manjusha, Yadla, Sri Ram Naveen, Parvathina, Krishna Kishore, Chennu, Sridhar, Anappindi, Siva Kumar, Vishnubotla
Format: Artikel
Sprache:eng
Schlagworte:
acute kidney injury
Acute Kidney Injury - chemically induced
Acute Kidney Injury - pathology
Adult
Animals
Female
hair dye
Hair Dyes - poisoning
hemodialysis
Humans
Kidney - pathology
Male
Middle Aged
paraphenylenediamine
Phenylenediamines - poisoning
poisoning
Rats
Young Adult
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Zusammenfassung:We studied paraphenylenediamine (PPD)-related acute kidney injury (AKI) in 81 patients and also in albino rats experimentally. In the patients' group AKI was found in 32.7%. Of them, 81.4% needed dialysis support. The overall mortality was 25.9%. In experimental rats the renal lesions were noted in all and they were glomerular congestion, intertubular (interstitial) hemorrhages, acute tubular necrosis, mesangial proliferation, and intratubular casts. The severity of renal injury appears to be dose dependent.
ISSN:0886-022X
1525-6049
DOI:10.3109/0886022X.2012.687346