Adverse Effects of Polyethylene Glycol and Phenytoin on the Rectal Mucosa of the Rat
Abstract The effects of polyethylene glycol (used as suppository base), a surfactant (Polyoxyl 59 stearate - Myrj 59®) and phenytoin on the rectal mucosa of the rat were investigated. Four different types of effects were observed in the 52 rats treated with the various polyethylene glycol, surfactan...
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| Veröffentlicht in: | Drug development and industrial pharmacy 1994, Vol.20 (8), p.1493-1502 |
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| container_title | Drug development and industrial pharmacy |
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| creator | Pienaar, E. W. Kriek, N. P. J. Boneschans, B. Koeleman, H. A. |
| description | Abstract
The effects of polyethylene glycol (used as suppository base), a surfactant (Polyoxyl 59 stearate - Myrj 59®) and phenytoin on the rectal mucosa of the rat were investigated. Four different types of effects were observed in the 52 rats treated with the various polyethylene glycol, surfactant and phenytoin combinations. Polyethylene glycol had a definite necrotic effect on the rectal mucosa of the rat. This adverse effect was more pronounced when phenytoin and polyoxyl 59 stearate were combined with the polyethylene glycol. |
| doi_str_mv | 10.3109/03639049409038385 |
| format | Article |
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The effects of polyethylene glycol (used as suppository base), a surfactant (Polyoxyl 59 stearate - Myrj 59®) and phenytoin on the rectal mucosa of the rat were investigated. Four different types of effects were observed in the 52 rats treated with the various polyethylene glycol, surfactant and phenytoin combinations. Polyethylene glycol had a definite necrotic effect on the rectal mucosa of the rat. This adverse effect was more pronounced when phenytoin and polyoxyl 59 stearate were combined with the polyethylene glycol.</description><identifier>ISSN: 0363-9045</identifier><identifier>EISSN: 1520-5762</identifier><identifier>DOI: 10.3109/03639049409038385</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>Biological and medical sciences ; Drug toxicity and drugs side effects treatment ; Medical sciences ; Pharmacology. Drug treatments ; Toxicity: digestive system</subject><ispartof>Drug development and industrial pharmacy, 1994, Vol.20 (8), p.1493-1502</ispartof><rights>1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-b0586c218eaca7f4ad4cd5c5c57250999c502cc620a182559db1bd1e2623b3013</citedby><cites>FETCH-LOGICAL-c377t-b0586c218eaca7f4ad4cd5c5c57250999c502cc620a182559db1bd1e2623b3013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/03639049409038385$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/03639049409038385$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4061899$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Pienaar, E. W.</creatorcontrib><creatorcontrib>Kriek, N. P. J.</creatorcontrib><creatorcontrib>Boneschans, B.</creatorcontrib><creatorcontrib>Koeleman, H. A.</creatorcontrib><title>Adverse Effects of Polyethylene Glycol and Phenytoin on the Rectal Mucosa of the Rat</title><title>Drug development and industrial pharmacy</title><description>Abstract
The effects of polyethylene glycol (used as suppository base), a surfactant (Polyoxyl 59 stearate - Myrj 59®) and phenytoin on the rectal mucosa of the rat were investigated. Four different types of effects were observed in the 52 rats treated with the various polyethylene glycol, surfactant and phenytoin combinations. Polyethylene glycol had a definite necrotic effect on the rectal mucosa of the rat. This adverse effect was more pronounced when phenytoin and polyoxyl 59 stearate were combined with the polyethylene glycol.</description><subject>Biological and medical sciences</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Toxicity: digestive system</subject><issn>0363-9045</issn><issn>1520-5762</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNp9kE9LAzEQxYMoWKsfwFsOXlfzZ7O7QS-l1CpULFLPy2w2YbekSUm2yn57t1YFEWQOAzPvN294CF1Scs0pkTeEZ1ySVKZEEl7wQhyhERWMJCLP2DEa7ffJIBCn6CzGNSGUSSFGaDWp33SIGs-M0aqL2Bu89LbXXdNb7TSe2155i8HVeNlo13e-ddg73DUavwwEWPy0Uz7CnvwcQneOTgzYqC---hi93s9W04dk8Tx_nE4WieJ53iUVEUWmGC00KMhNCnWqaqGGypkgUkolCFMqYwRowYSQdUWrmmqWMV5xQvkY0cNdFXyMQZtyG9oNhL6kpNzHUv6JZWCuDswWogJrAjjVxh8wJRktpBxkdwdZ64wPG3j3wdZlB7314Zvh_7nc_sIbDbZrFARdrv0uuCGVf378AApCho4</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>Pienaar, E. W.</creator><creator>Kriek, N. P. J.</creator><creator>Boneschans, B.</creator><creator>Koeleman, H. A.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1994</creationdate><title>Adverse Effects of Polyethylene Glycol and Phenytoin on the Rectal Mucosa of the Rat</title><author>Pienaar, E. W. ; Kriek, N. P. J. ; Boneschans, B. ; Koeleman, H. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-b0586c218eaca7f4ad4cd5c5c57250999c502cc620a182559db1bd1e2623b3013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Biological and medical sciences</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Toxicity: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pienaar, E. W.</creatorcontrib><creatorcontrib>Kriek, N. P. J.</creatorcontrib><creatorcontrib>Boneschans, B.</creatorcontrib><creatorcontrib>Koeleman, H. A.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Drug development and industrial pharmacy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pienaar, E. W.</au><au>Kriek, N. P. J.</au><au>Boneschans, B.</au><au>Koeleman, H. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adverse Effects of Polyethylene Glycol and Phenytoin on the Rectal Mucosa of the Rat</atitle><jtitle>Drug development and industrial pharmacy</jtitle><date>1994</date><risdate>1994</risdate><volume>20</volume><issue>8</issue><spage>1493</spage><epage>1502</epage><pages>1493-1502</pages><issn>0363-9045</issn><eissn>1520-5762</eissn><abstract>Abstract
The effects of polyethylene glycol (used as suppository base), a surfactant (Polyoxyl 59 stearate - Myrj 59®) and phenytoin on the rectal mucosa of the rat were investigated. Four different types of effects were observed in the 52 rats treated with the various polyethylene glycol, surfactant and phenytoin combinations. Polyethylene glycol had a definite necrotic effect on the rectal mucosa of the rat. This adverse effect was more pronounced when phenytoin and polyoxyl 59 stearate were combined with the polyethylene glycol.</abstract><cop>Colchester</cop><pub>Informa UK Ltd</pub><doi>10.3109/03639049409038385</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-9045 |
| ispartof | Drug development and industrial pharmacy, 1994, Vol.20 (8), p.1493-1502 |
| issn | 0363-9045 1520-5762 |
| language | eng |
| recordid | cdi_informahealthcare_journals_10_3109_03639049409038385 |
| source | Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Biological and medical sciences Drug toxicity and drugs side effects treatment Medical sciences Pharmacology. Drug treatments Toxicity: digestive system |
| title | Adverse Effects of Polyethylene Glycol and Phenytoin on the Rectal Mucosa of the Rat |
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