Adverse Effects of Polyethylene Glycol and Phenytoin on the Rectal Mucosa of the Rat

Abstract The effects of polyethylene glycol (used as suppository base), a surfactant (Polyoxyl 59 stearate - Myrj 59®) and phenytoin on the rectal mucosa of the rat were investigated. Four different types of effects were observed in the 52 rats treated with the various polyethylene glycol, surfactan...

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Veröffentlicht in:	Drug development and industrial pharmacy 1994, Vol.20 (8), p.1493-1502
Hauptverfasser:	Pienaar, E. W., Kriek, N. P. J., Boneschans, B., Koeleman, H. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Drug toxicity and drugs side effects treatment Medical sciences Pharmacology. Drug treatments Toxicity: digestive system
Online-Zugang:	Volltext
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Zusammenfassung:	Abstract The effects of polyethylene glycol (used as suppository base), a surfactant (Polyoxyl 59 stearate - Myrj 59®) and phenytoin on the rectal mucosa of the rat were investigated. Four different types of effects were observed in the 52 rats treated with the various polyethylene glycol, surfactant and phenytoin combinations. Polyethylene glycol had a definite necrotic effect on the rectal mucosa of the rat. This adverse effect was more pronounced when phenytoin and polyoxyl 59 stearate were combined with the polyethylene glycol.
ISSN:	0363-9045 1520-5762
DOI:	10.3109/03639049409038385